If you have never seen The Graduate, you can’t really call yourself a film buff. This astounding 1967 movie, directed by the late, great Mike Nichols, co-written by Buck Henry, and starring Dustin Hoffman and Anne Bancroft, took the world by storm when it was first released. The bizarre love triangle – boy has affair with married woman, then falls in love with her daughter – is riveting, and under Nichols’s direction, the blend of comedy and drama are interwoven perfectly.

McConaughey famously lost more than 40 pounds to portray real-life AIDS victim Ron Woodruff. The Dallas resident refused to see his disease as a death sentence and began smuggling experimental medications into the U.S., then selling them to others with HIV. Leto plays a transgender woman named Rayon, who was created by screenwriters as a composite of numerous people in Woodruff’s life.